A Comparative Evaluation of a Novel Vaccine in APP/PS1 Mouse Models of Alzheimer’s Disease

Figure 4

Comparative quantification of Aβ burden area in the brain of APP/PS1 mice. Quantitative analysis of Aβ burden area in the hippocampal and cortical regions of APPswe/PS1ΔE9 mice treated with EB101, Aβ/liposomes, S1P/liposomes, + FA/IFA, and PBS, represented by the number of pixels inside the stained area of each Aβ plaque. This graphic shows that Aβ plaques of EB101-treated mice (Group A) are significantly smaller in size () than those of the other four treatment groups. Data are presented as mean ± SEM. Mean of Aβ plaques area in Tg mice hippocampus.