A Comparative Evaluation of a Novel Vaccine in APP/PS1 Mouse Models of Alzheimer’s Disease

Figure 8

Analysis of motor coordination and balance. (a) Rotarod results of motor coordination and balance test after the preventive and therapeutic treatment showing improved effect of EB101 and + CFA/IFA-vaccine compared to other treated mice groups () and () versus control mice. Latency to fall on the rotarod apparatus was significantly improved in EB101 immunized mice. Values represent means of all six trials of a group/day. (b) Spatial learning and memory tested by fear conditioning-active avoidance test. The mean response time of each treatment group to reach the platform is represented. EB101 and + CFA/IFA immunized mice had significantly lower latencies than the other treatment groups () versus control mice.

(a) Graphic of motor coordination and balance

(b) Graphic of associative learning and memory