Altered Expression Levels of MMP1, MMP9, MMP12, TIMP1, and IL-1 as a Risk Factor for the Elevated IOP and Optic Nerve Head Damage in the Primary Open-Angle Glaucoma Patients

Table 1

The clinical characteristic of open-angle glaucoma (POAG) patients and control group.

	Parameter	Patient groups	Control group
Percentage of the group	Gender; male/female	38%/62%	52%/48%
	Hypertension^a	54%	70%
	Low blood pressure^b	40%	29%
	Vascular disease	33%	49%
	Diabetes mellitus type 2^d	17%	55%
Mean ± SD	Age (years)	73 ± 10	64 ± 1 6
	Intraocular pressure, IOP (mmHg)	13.2 ± 2.9	11.9 ± 1.9
	Cup disk ratio (c/d); right eye/left eye	0.72 ± 0.16/0.70 ± 0.16	PNM^c
	Rim area (RA); right eye/left eye	1.19 ± 0.43/1.25 ± 0.37	PNM^c
	Retinal nerve fiber layer (RNFL); right eye/left eye	0.18 ± 0.08/0.23 ± 0.22	PNM^c

Systolic pressure > 140; diastolic pressure > 90 mmHg.
^bSystolic pressure < 90; diastolic pressure < 60 mmHg.
^cPNM: Parameter not measured.
^dNo differences observed for the studied proteins expression level when DM and non-DM subjects were compared in each group ().
After the treatment: all of the patients enrolled to this study had increased IOP above 21 with the average of 23.3 ± 1.9 measurement taken during first appointment prior to antiglaucoma treatment.