Identification of Potential Transcriptomic Markers in Developing Ankylosing Spondylitis: A Meta-Analysis of Gene Expression Profiles

Table 2

The 10 most significantly upregulated and 10 most significantly downregulated genes in ankylosing spondylitis.

Entrez ID	Gene symbol	Gene full name	Combined rank product	Average log fold change
10 most significantly upregulated genes
2791	GNG11	Guanine nucleotide binding protein (G protein), gamma 11	299.64	0.380467
51372	TMA7	Translation machinery associated 7 homolog (S. cerevisiae)	312.39	0.610581
9349	RPL23	Ribosomal protein L23	324.13	0.148532
23643	LY96	Lymphocyte antigen 96	330.33	0.195432
170622	COMMD6	COMM domain containing 6	332.47	0.293187
5909	RAP1GAP	RAP1 GTPase activating protein	343.66	0.223733
1349	COX7B	Cytochrome c oxidase subunit VIIb	371.12	0.132367
6283	S100A12	S100 calcium binding protein A12	439.12	0.334567
27258	LSM3	LSM3 homolog, U6 small nuclear RNA associated (S. cerevisiae)	440.15	0.596028
199675	C19orf59	Chromosome 19 open reading frame 59	494.30	0.358146
10 most significantly downregulated genes
6286	S100P	S100 calcium binding protein P	335.94	−0.199948
3560	IL2RB	Interleukin 2 receptor, beta	351.04	−0.166370
221178	SPATA13	Spermatogenesis associated 13	473.13	−0.442046
9289	GPR56	G protein-coupled receptor 56	528.50	−0.239562
22848	AAK1	AP2 associated kinase 1	530.65	−0.364595
5551	PRF1	Perforin 1 (pore forming protein)	531.02	−0.114758
1236	CCR7	Chemokine (C-C motif) receptor 7	609.87	−0.199449
1524	CX3CR1	Chemokine (C-X3-C motif) receptor 1	622.12	−0.351950
1675	CFD	Complement factor D (adipsin)	636.15	−0.365854
83888	FGFBP2	Fibroblast growth factor binding protein 2	653.39	−1.054696