Research Article
Identification of Potential Transcriptomic Markers in Developing Ankylosing Spondylitis: A Meta-Analysis of Gene Expression Profiles
Table 2
The 10 most significantly upregulated and 10 most significantly downregulated genes in ankylosing spondylitis.
| Entrez ID | Gene symbol | Gene full name | Combined rank product | Average log fold change |
| 10 most significantly upregulated genes | | | 2791 | GNG11 | Guanine nucleotide binding protein (G protein), gamma 11 | 299.64 | 0.380467 | 51372 | TMA7 | Translation machinery associated 7 homolog (S. cerevisiae) | 312.39 | 0.610581 | 9349 | RPL23 | Ribosomal protein L23 | 324.13 | 0.148532 | 23643 | LY96 | Lymphocyte antigen 96 | 330.33 | 0.195432 | 170622 | COMMD6 | COMM domain containing 6 | 332.47 | 0.293187 | 5909 | RAP1GAP | RAP1 GTPase activating protein | 343.66 | 0.223733 | 1349 | COX7B | Cytochrome c oxidase subunit VIIb | 371.12 | 0.132367 | 6283 | S100A12 | S100 calcium binding protein A12 | 439.12 | 0.334567 | 27258 | LSM3 | LSM3 homolog, U6 small nuclear RNA associated (S. cerevisiae) | 440.15 | 0.596028 | 199675 | C19orf59 | Chromosome 19 open reading frame 59 | 494.30 | 0.358146 |
| 10 most significantly downregulated genes | | | 6286 | S100P | S100 calcium binding protein P | 335.94 | −0.199948 | 3560 | IL2RB | Interleukin 2 receptor, beta | 351.04 | −0.166370 | 221178 | SPATA13 | Spermatogenesis associated 13 | 473.13 | −0.442046 | 9289 | GPR56 | G protein-coupled receptor 56 | 528.50 | −0.239562 | 22848 | AAK1 | AP2 associated kinase 1 | 530.65 | −0.364595 | 5551 | PRF1 | Perforin 1 (pore forming protein) | 531.02 | −0.114758 | 1236 | CCR7 | Chemokine (C-C motif) receptor 7 | 609.87 | −0.199449 | 1524 | CX3CR1 | Chemokine (C-X3-C motif) receptor 1 | 622.12 | −0.351950 | 1675 | CFD | Complement factor D (adipsin) | 636.15 | −0.365854 | 83888 | FGFBP2 | Fibroblast growth factor binding protein 2 | 653.39 | −1.054696 |
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