Crocetin Downregulates the Proinflammatory Cytokines in Methylcholanthrene-Induced Rodent Tumor Model and Inhibits COX-2 Expression in Cervical Cancer Cells

Figure 5

Crocetin inhibited COX-2 production and expression in HeLa cells. (a) Expression analysis of COX-2 in HeLa cells. Lane U shows untreated HeLa cells; lane T shows crocetin-treated HeLa cells; lane N shows negative control for RT-PCR. β-Actin was used as an internal control. Representative gels from one of the three experiments were used. (b) The mRNA level of COX-2 was measured in HeLa cells treated with various concentrations of crocetin for 24 h. Values represent the mean ± SEM. ^* versus control group.

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