Biological Roles of Resolvins and Related Substances in the Resolution of Pain

Figure 1

Endogenous biosynthetic pathways of the E-series resolvins (RvEs). Eicosapentaenoic acid (EPA) is converted into 18-hydroperoxy-EPE (18-HpEPE) by aspirin-treated cyclooxygenase-2 (COX-2) or cytochrome P450 (CYP450) and subsequently transformed by 5-lipoxygenase (5-LOX) into RvE1 and RvE2.