Integrative Analysis with Monte Carlo Cross-Validation Reveals miRNAs Regulating Pathways Cross-Talk in Aggressive Breast Cancer

Table 2

Top 10 pairs of pathways with AUC value for TCGA testing and GEO dataset.

Pairs of pathways	TCG AUC	GSE39004 AUC
(1a) Acute Phase Response Signaling
(1b) HIF1 Signaling	0.92	0.889
(2a) HIF1 Signaling
(2b) Fatty Acid oxidation	0.955	0.654
(3a) Ethanol Degradation IV
(3b) Estrogen Receptor Signaling	0.925	0.656
(4a) HIF1 Signaling
(4b) Tryptophan Degradation X (Mammalian, via Tryptamine)	0.922	0.629
(5a) Bladder Cancer Signaling
(5b) Fatty Acid oxidation	0.932	0.84
(6a) Human Embryonic Stem Cell Pluripotency
(6b) Putrescine Degradation III	0.931	0.613
(7a) Bladder Cancer Signaling
(7b) Tryptophan Degradation X (Mammalian, via Tryptamine)	0.91	0.802
(8a) Intrinsic Prothrombin Activation Pathway
(8b) Extrinsic Prothrombin Activation Pathway	0.911	0.581
(9a) Cardiac adrenergic Signaling
(9b) Fatty Acid oxidation	0.916	0.732
(10a) Human Embryonic Stem Cell Pluripotency
(10b) Fatty Acid oxidation	0.926	0.615