Integrative Analysis with Monte Carlo Cross-Validation Reveals miRNAs Regulating Pathways Cross-Talk in Aggressive Breast Cancer

Table 3

Differentially expressed miRNA-regulating pathway cross-talk. ex.BC indicates miRNA expression levels in BC and ex.NS indicates miRNA expression levels in NS.

Pairs Pathways	miRNA	logFC	ex.BC	ex.NS	Delta
(1a) Human Embryonic Stem Cell Pluripotency
(1b) Putrescine Degradation III	hsa-let-7c	−1.507	12801.77	27353.99	21938.10
(2a) Intrinsic Prothrombin Activation Pathway
(2b) Extrinsic Prothrombin Activation Pathway	hsa-mir-210	3.273	2702.47	317.80	6433.72
(3a) Intrinsic Prothrombin Activation Pathway
(3b) Extrinsic Prothrombin Activation Pathway	hsa-mir-9-1	1.925	4679.87	1339.12	7806.52
(4a) Intrinsic Prothrombin Activation Pathway
(4b) Extrinsic Prothrombin Activation Pathway	hsa-mir-483	−1.786	22.80	67.85	28.86
(5a) Intrinsic Prothrombin Activation Pathway
(5b) Extrinsic Prothrombin Activation Pathway	hsa-mir-592	4.156	16.77	0.7	80.44
(6a) Ethanol Degradation IV
(6b) Estrogen Receptor Signaling	hsa-mir-103-2	1.134	48.07	19.65	32.24
(7a) Intrinsic Prothrombin Activation Pathway
(7b) Extrinsic Prothrombin Activation Pathway	hsa-mir-887	1.094	50.56	24.18	66.81
(8a) Acute Phase Response Signaling
(8b) HIF1 Signaling	hsa-mir-181b-2	1.432	23.47	8.02	22.14
(9a) Intrinsic Prothrombin Activation Pathway
(9b) Extrinsic Prothrombin Activation Pathway	hsa-mir-301b	2.608	4.75	0.78	10.36
(10a) Intrinsic Prothrombin Activation Pathway
(10b) Extrinsic Prothrombin Activation Pathway	hsa-mir-147b	2.312	3.99	0.701	7.61
(11a) Intrinsic Prothrombin Activation Pathway
(11b) Extrinsic Prothrombin Activation Pathway	hsa-mir-665	−1.447	2.28	5.56	3.88
(12a) Intrinsic Prothrombin Activation Pathway
(12b) Extrinsic Prothrombin Activation Pathway	hsa-mir-939	1.110	5.93	2.43	4.74