Integrative Analysis with Monte Carlo Cross-Validation Reveals miRNAs Regulating Pathways Cross-Talk in Aggressive Breast Cancer

Table 4

Differentially expressed miRNA-regulating pathway cross-talk with mutual information: p.a ng indicates the number of genes for pathway a; mirna.p.a indicates the number of miRNA targets for pathway a; p.b ng indicates the number of genes for pathway b; mirna.p.b indicates the number of miRNA targets for pathway b.

Pairs Pathways	miRNA	p.a ng	mirna.p.a	p.b ng	mirna.p.b
(1a) Human Embryonic Stem Cell Pluripotency
(1b) Putrescine Degradation III	hsa-let-7c	104	40	16	8
(2a) Intrinsic Prothrombin Activation Pathway
(2b) Extrinsic Prothrombin Activation Pathway	hsa-mir-9-1	19	9	12	4
(3a) Intrinsic Prothrombin Activation Pathway
(3b) Extrinsic Prothrombin Activation Pathway	hsa-mir-210	19	9	12	8
(4a) Intrinsic Prothrombin Activation Pathway
(4b) Extrinsic Prothrombin Activation Pathway	hsa-mir-592	19	5	12	4
(5a) Intrinsic Prothrombin Activation Pathway
(5b) Extrinsic Prothrombin Activation Pathway	hsa-mir-887	19	7	12	6
(6a) Ethanol Degradation IV
(6b) Estrogen Receptor Signaling	hsa-mir-103-2	17	4	112	15
(7a) Intrinsic Prothrombin Activation Pathway
(7b) Extrinsic Prothrombin Activation Pathway	hsa-mir-483	19	6	12	5
(8a) Acute Phase Response Signaling
(8b) HIF1 Signaling	hsa-mir-181b-2	146	26	94	19
(9a) Intrinsic Prothrombin Activation Pathway
(9b) Extrinsic Prothrombin Activation Pathway	hsa-mir-301b	19	7	12	5
(10a) Intrinsic Prothrombin Activation Pathway
(10b) Extrinsic Prothrombin Activation Pathway	hsa-mir-147b	19	5	12	5
(11a) Intrinsic Prothrombin Activation Pathway
(11b) Extrinsic Prothrombin Activation Pathway	hsa-mir-939	19	8	12	5
(12a) Intrinsic Prothrombin Activation Pathway
(12b) Extrinsic Prothrombin Activation Pathway	hsa-mir-665	19	7	12	4