Research Article
Integrative Analysis with Monte Carlo Cross-Validation Reveals miRNAs Regulating Pathways Cross-Talk in Aggressive Breast Cancer
Table 5
Principal target genes of miRNA-regulating pathway cross-talk in NS versus BC.
| Pairs Pathways | miRNAs | Genes (a) | Genes (b) |
| (1a) Human Embryonic Stem Cell Pluripotency (1b) Putrescine Degradation III | hsa-let-7c | ACVR1 BMP4 | ALDH1A1 ALDH1A21 | | BMP5 BMP6 | ALDH2 ALDH4A1 | | FGF2 FZD7 | ALDH9A1 IL4I1 | | KLK3 LEFTY2 | MAOA SMOX | | MRAS NTRK2 | | | NTRK3 PDGFRA | | | PDGFRB PIK3CB | | | PIK3CD PIK3R6 | | | S1PR1 SPHK1 | | | TCF4 TCF7L1 | | | TGFB1 TGFBR2 | | | WNT11 WNT6 | |
| (2a) Ethanol Degradation IV (2b) Estrogen Receptor Signaling | hsa-mir-103-2 | ACSS2 ALDH1A1 | EP300 GTF2B | | ALDH3A1 ALDH9A1 | GTF2H3 MED15 | | | MED17 MED6 | | | NCOR1 NCOR2 | | | PCK1 POLR2E | | | TAF3 TAF7 |
| (3a) Acute Phase Response Signaling (3b) HIF1 Signaling | hsa-mir-181b-2 | ELK1 HNRNPK | ARNT EGLN2 | | IKBKB KRAS | EP300 EPO | | MAP2K7 MAPK1 | KRAS MAPK1 | | MAPK3 MRAS | MAPK3 MMP23B | | NRAS OSM | MRAS NRAS | | PIK3CB PIK3R2 | PIK3CB PIK3R2 | | PTPN11 SOCS4 | SLC2A3 VHL |
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