Integrative Analysis with Monte Carlo Cross-Validation Reveals miRNAs Regulating Pathways Cross-Talk in Aggressive Breast Cancer

Table 5

Principal target genes of miRNA-regulating pathway cross-talk in NS versus BC.

Pairs Pathways	miRNAs	Genes (a)	Genes (b)
(1a) Human Embryonic Stem Cell Pluripotency; (1b) Putrescine Degradation III	hsa-let-7c	ACVR1 BMP4	ALDH1A1 ALDH1A21
		BMP5 BMP6	ALDH2 ALDH4A1
		FGF2 FZD7	ALDH9A1 IL4I1
		KLK3 LEFTY2	MAOA SMOX
		MRAS NTRK2
		NTRK3 PDGFRA
		PDGFRB PIK3CB
		PIK3CD PIK3R6
		S1PR1 SPHK1
		TCF4 TCF7L1
		TGFB1 TGFBR2
		WNT11 WNT6
(2a) Ethanol Degradation IV; (2b) Estrogen Receptor Signaling	hsa-mir-103-2	ACSS2 ALDH1A1	EP300 GTF2B
		ALDH3A1 ALDH9A1	GTF2H3 MED15
			MED17 MED6
			NCOR1 NCOR2
			PCK1 POLR2E
			TAF3 TAF7
(3a) Acute Phase Response Signaling; (3b) HIF1 Signaling	hsa-mir-181b-2	ELK1 HNRNPK	ARNT EGLN2
		IKBKB KRAS	EP300 EPO
		MAP2K7 MAPK1	KRAS MAPK1
		MAPK3 MRAS	MAPK3 MMP23B
		NRAS OSM	MRAS NRAS
		PIK3CB PIK3R2	PIK3CB PIK3R2
		PTPN11 SOCS4	SLC2A3 VHL