The Sea Lamprey as an Etiological Model for Biliary Atresia

Figure 5

Liver morphology in large parasitic ((a) and (b)), adult male (c) and adult female (d) sea lamprey. (a) Steatosis (white vacuoles in hepatocytes) and macrophage recruitment and activation (yellow cells with filopodia). Note that there are clusters of lymphocytes and macrophages at the fibrotic site. (b) Activated macrophages (yellow cells with filopodia) clearing fibrosis (red) and steatosis (white vacuoles in hepatocytes). (c) Collagen deposition around the basement membrane of blood vessels (red), activated macrophages (yellow cells with filopodia) clearing fibrosis (red) and steatosis (white vacuoles in hepatocytes). (d) Collagen deposition around the basement membrane of blood vessels (red), activated macrophages (yellow cells with filopodia) clearing fibrosis (red) and no steatosis. Paraffin sections were stained with Picro Sirius Red (Gladstone). Scale bar: 50 μm.

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