Gene Expression-Genotype Analysis Implicates GSDMA, GSDMB, and LRRC3C as Contributors to Inflammatory Bowel Disease Susceptibility

Table 1

Clinical characteristics of participants.

	IBD; ( = 52)	Non-IBD; ( = 33)
Disease (CD/UC/IBDU)	21/29/2
Disease (non-IBD)		a
Gender (male/female)	23/29	13/20
Age (years)	40 (18–77)	49 (20–82)
Smoker (yes/previous/no/no data)	6/5/35/6	3/2/23/5
Immune-modulating drugs
Aminosalicylates	24	0
Thiopurines	17	0
Corticosteroids	17	0
Anti-TNF-α-antibodies	6	1
Methotrexate	2	1
Tacrolimus	2	1
None	10	33

Patients were referred for investigation of gastrointestinal symptoms (e.g., diarrhea, fecal blood, or abdominal pain) or for screening for colorectal adenomas with the following findings: diverticulosis ( = 4), polyps ( = 5), low-grade dysplasia adenomas ( = 2), colorectal cancer ( = 2), hemorrhoids ( = 3), radiation proctitis ( = 1), or without pathological findings ( = 19). There were two instances of simultaneous diverticulosis and polyps and one instance of simultaneous diverticulosis and hemorrhoids.
Median (range) values are given.