Gene Expression-Genotype Analysis Implicates GSDMA, GSDMB, and LRRC3C as Contributors to Inflammatory Bowel Disease Susceptibility

Table 2

Spearman’s rank correlation between the genotype of rs2872507 (number of susceptibility alleles) and gene expression (dCt-values) in intestinal biopsy samples from different study groups.

Genes	NI_N_il	NI_N_co	IBD_N_il	IBD_N_co	IBD_I_co	CD_N_il	CD_N_co	UC_N_il	UC_N_co	UC_I_co
	= 24	= 33	= 24	= 29	= 28	= 11	= 12	= 12	= 16	= 19
	P value	P value	P value	P value	P value	P value	P value	P value	P value	P value
PGAP3	0.37	6.8 × 10^−03	2.0 × 10^−03	0.019	0.017	0.030	0.43	0.29	0.060	0.59
ERBB2	0.64	0.57	0.69	0.27	0.23	0.91	0.31	0.50	0.68	0.89
MIEN1	0.66	0.89	0.034	0.15	0.50	0.79	0.35	0.085	0.023	0.27
GRB7	0.93	0.71	0.21	0.61	0.99	0.51	0.93	0.31	0.93	0.50
IKZF3	0.88	0.85	0.69	0.43	0.47	0.42	0.39	0.80	0.92	0.27
ZPBP2	0.24	0.59	0.84	0.33	0.17	7.7 × 10^−04	0.95	0.76	0.078	0.064
GSDMB	2.4 × 10^−03	3.7 × 10^−04	1.5 × 10^−03	7.2 × 10^−10	4.1 × 10^−03	3.8 × 10^−03	6.2 × 10^−06	0.035	1.9 × 10^−04	0.045
ORMDL3	0.92	0.77	0.037	0.35	0.47	0.016	0.63	0.24	0.045	0.22
LRRC3C	0.83	7.8 × 10^−06	0.92	0.058	0.42	0.79	0.58	0.21	0.24	0.27
GSDMA	0.016	1.6 × 10^−04	0.92	0.28	0.15	0.28	0.50	0.74	0.50	0.86
PSMD3	0.87	0.38	0.51	0.014	0.43	0.45	0.057	0.66	0.14	0.32
CSF3	0.42	0.45	0.61	0.66	0.81	0.77	0.31	0.25	0.17	0.10
MED24	0.39	0.43	0.16	6.9 × 10^−03	0.61	0.50	0.085	0.76	0.093	0.21

Disease status_Inflammatory status_sampling location; the disease statuses are Crohn’s disease (CD), inflammatory bowel disease (IBD), non-IBD (NI), and ulcerative colitis (UC); the inflammatory statuses are inflamed (I) and noninflamed (N); the sampling locations are colon (co) and ileum (il).
Genes have been arranged (top to bottom) in the order in which they are positioned along the chromosome, and the risk locus (rs2872507) is located between ZPBP2 and GSDMB (closer to ZPBP2).