Gene Expression-Genotype Analysis Implicates GSDMA, GSDMB, and LRRC3C as Contributors to Inflammatory Bowel Disease Susceptibility

Table 3

Inflammatory effects on the colonic mucosal expression of genes in the IBD risk locus (rs2872507).

Genes	IBD_N_co ( = 29) versus IBD_I_co ( = 28)		UC_N_co ( = 16) versus UC_I_co ( = 19)		CD_N_co ( = 12) versus CD_I_co ( = 7)
	P value	Fold change	P value	Fold change	P value	Fold change
PGAP3	3.7 × 10^−09		9.8 × 10^−06		4.5 × 10^−04
ERBB2	1.0 × 10^−09		3.9 × 10^−06		6.2 × 10^−04
MIEN1	1.0 × 10^−04		0.014		0.010
GRB7	1.7 × 10^−07		2.9 × 10^−04		8.4 × 10^−04
IKZF3	2.4 × 10^−07		6.6 × 10^−05		6.0 × 10^−03
ZPBP2	0.21		0.27		0.58
GSDMB	0.31		0.33		0.97
ORMDL3	0.65		0.56		0.64
LRRC3C	0.016		0.18		0.083
GSDMA	0.48		0.96		0.29
PSMD3	0.024		0.030		0.33
CSF3	3.5 × 10^−08		4.3 × 10^−05		2.7 × 10^−03
MED24	6.5 × 10^−03		9.3 × 10^−03		0.42

Disease status_Inflammatory status_sampling location; the disease statuses are Crohn’s disease (CD), inflammatory bowel disease (IBD), and ulcerative colitis (UC); the inflammatory statuses are inflamed (I) and noninflamed (N); the sampling locations are colon (co) and ileum (il).
Genes have been arranged (top to bottom) in the order in which they are positioned along the chromosome.
A negative fold change indicates reduced expression in the inflamed tissue compared with that in the noninflamed tissue.