Chemotherapy and Chemoprevention by Thiazolidinediones

Figure 2

Effects of TZDs on apoptosis, migration, invasion, and proliferation of cancer cells and on inflammation. In some ellipses, only one representative is listed; Bax and p53 react similarly, as well as p27 and p21. MMPs represents MMP-2 and MMP-9 and Cyclin E represents cyclin D1, cyclin B1, CDK2, and CDK4. Abbreviations: EGF: epithelial growth factor receptor; PPRE: PPAR response element, Surv: survivin, E-cad: E-cadherin, b-cat: -catenin, Cytok: cytokines.