Chemotherapy and Chemoprevention by Thiazolidinediones

Table 2

Summary of data on chemopreventive effects of TZDs in animal and human epidemiological studies.

Cancer type	Role of PPAR expression	TZD	Experimental model	Result	Reference
		PIO	Chemically-induced rat cancer model	Reduction of tumor incidence	[121]
Colon	/		Transgenic murine cancer model (nonsense mutation in the adenomatous polyposis coli)	Increase of tumor incidence	[122]
		TRO	Chemically-induced rat cancer model	Reduction of tumor incidence	[123]
		ROSI	Meta-analysis of diabetes trials	Reduced colon cancer incidence	[64]
Lung	/	PIO	Chemically induced murine cancer model	Reduction of tumor incidence	[72]
		PIO	Observational study	Reduced lung cancer incidence	[63]
Breast		PIO	Meta-analysis of diabetes trials	Reduced breast cancer incidence	[64]
Liver		PIO	Chemically induced rat cancer model	Reduced tumor incidence	[73]
Endometrium		ROSI	Transgenic murine cancer model	Reduced tumor incidence	[12]
Oral (squamous cancer)		PIO	Transgenic rat cancer model	Reduced tumor incidence	[77]
		TRO	Chemically induced rat cancer model	Reduced tumor incidence	[78]

PPAR expression on tumor progression: promotion: ; protection: .