Multifaceted Roles of Cysteinyl Leukotrienes in Eliciting Eosinophil Granule Protein Secretion

<div>Stimulating cell-free eosinophil granules with the agonists LTC<sub>4</sub>, LTD<sub>4</sub>, and LTE<sub>4</sub> elicited the secretion of eosinophil cationic protein (ECP) but not eosinophil-derived cytokines or chemokines from the granules. Cysteinyl leukotriene receptor (cysLTR) or P2Y12 receptor (P2Y12R) blockers inhibited ECP secretion after LTC<sub>4</sub>/LTD<sub>4</sub>/LTE<sub>4</sub> stimulation of cell-free eosinophil granules.</div>

BioMed Research International

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Figure 2

Figure 2: Multifaceted Roles of Cysteinyl Leukotrienes in Eliciting Eosinophil Granule Protein Secretion 