Potentially Functional Polymorphisms in POU5F1 Gene Are Associated with the Risk of Lung Cancer in Han Chinese
Table 2
Summary of associations between 17 SNPs in selected POU5F1 gene with lung cancer risk.
SNP
Allele
Case
Control
Call rate (%)
MAF (case/control)
HWE
OR (95% CI)
rs887468
G/A
997/322/22
1588/368/26
100.00
0.14/0.11
0.35
1.29 (1.11–1.51)
0.001
0.017
rs3130457
A/G
1030/293/18
1626/335/21
100.00
0.12/0.10
0.43
1.29 (1.10–1.51)
0.002
0.034
rs12215963
A/G
1102/221/8
1694/254/9
98.95
0.09/0.07
1.00
1.26 (1.05, 1.53)
0.015
0.255
rs885948
A/G
321/665/355
530/1000/452
100.00
0.51/0.48
0.65
1.13 (1.02, 1.25)
0.022
0.374
rs4713438
G/A
978/335/28
1391/552/39
100.00
0.15/0.16
0.07
0.90 (0.78, 1.04)
0.169
1.000
rs2269713
A/G
875/411/55
1337/579/66
100.00
0.19/0.18
0.70
1.09 (0.96, 1.24)
0.181
1.000
rs1052989
G/A
556/611/174
772/931/279
100.00
0.36/0.38
0.96
0.93 (0.84, 1.04)
0.201
1.000
rs885950
A/C
463/636/241
722/930/322
99.73
0.42/0.40
0.45
1.07 (0.96, 1.18)
0.208
1.000
rs879882
A/G
342/676/323
553/964/465
100.00
0.49/0.48
0.26
1.06 (0.96, 1.18)
0.227
1.000
rs2394882
C/A
617/577/147
851/914/217
100.00
0.32/0.34
0.23
0.94 (0.84, 1.04)
0.239
1.000
rs9468877
G/A
1141/193/7
1718/256/8
100.00
0.08/0.07
0.86
1.12 (0.92, 1.35)
0.275
1.000
rs1108746
C/A
1097/233/11
1607/356/19
100.00
0.10/0.10
1.00
0.95 (0.80, 1.12)
0.541
1.000
rs1265156
C/A
589/579/173
835/900/247
100.00
0.34/0.35
0.84
0.97 (0.88, 1.08)
0.597
1.000
rs887464
G/A
487/628/226
684/963/335
100.00
0.40/0.41
0.93
0.97 (0.88, 1.08)
0.625
1.000
rs3130503
G/A
791/485/65
1154/726/102
100.00
0.23/0.23
0.42
0.98 (0.87, 1.11)
0.773
1.000
rs3094188
A/C
834/452/55
1250/650/82
100.00
0.21/0.21
0.89
1.02 (0.90, 1.15)
0.775
1.000
rs887466
G/A
403/656/281
587/981/413
99.94
0.45/0.46
0.93
1.00 (0.90, 1.10)
0.955
1.000
Major/minor allele. Major homozygote/heterozygote/rare homozygote between cases and controls. Minor allele frequency. Hardy-Weinberg equilibrium test among controls. Logistic regression with adjustment for age, sex, and pack-year of smoking in additive model. values of false discovery rate (FDR).
