Research Article
Potentially Functional Polymorphisms in POU5F1 Gene Are Associated with the Risk of Lung Cancer in Han Chinese
Table 3
Associations between 2 functional SNPs in POU5F1 gene with lung cancer risk.
| Genotype | Case () | Control () | OR (95% CI) | |
| rs887468 (G>A) | | | | | GG | 997 | 1588 | 1.00 | | GA | 322 | 368 | 1.33 (1.12–1.59) | 0.001 | AA | 22 | 26 | 1.39 (0.78–2.49) | 0.269 | Additive model | 1341 | 1982 | 1.29 (1.11–1.51) | 0.001 | rs3130457 (A>G) | | | | | AA | 1030 | 1626 | 1.00 | | AG | 293 | 335 | 1.31 (1.10–1.57) | 0.003 | GG | 18 | 21 | 1.44 (0.76–2.76) | 0.265 | Additive model | 1341 | 1982 | 1.29 (1.10–1.51) | 0.002 |
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Major allele > Minor allele. Logistic regression with adjustment for age, gender, and pack-years of smoking.
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