Potentially Functional Polymorphisms in POU5F1 Gene Are Associated with the Risk of Lung Cancer in Han Chinese

Table 3

Associations between 2 functional SNPs in POU5F1 gene with lung cancer risk.

Genotype	Case ()	Control ()	OR (95% CI)
rs887468 (G>A)
GG	997	1588	1.00
GA	322	368	1.33 (1.12–1.59)	0.001
AA	22	26	1.39 (0.78–2.49)	0.269
Additive model	1341	1982	1.29 (1.11–1.51)	0.001
rs3130457 (A>G)
AA	1030	1626	1.00
AG	293	335	1.31 (1.10–1.57)	0.003
GG	18	21	1.44 (0.76–2.76)	0.265
Additive model	1341	1982	1.29 (1.10–1.51)	0.002

Major allele > Minor allele. Logistic regression with adjustment for age, gender, and pack-years of smoking.