Review Article
Participation of WNT and β-Catenin in Physiological and Pathological Endometrial Changes: Association with Angiogenesis
Table 1
Function and hormonal regulation of WNT and β-catenin (CTNNB1 gene) in the endometrium.
|
Gene | Description | References |
| WNT4 | Function | Formation of the primordial gonads | [18] | Gametogenesis | [17] | Uterine wall morphogenesis | [19] | Decidua formation | [24, 60, 88] | Hormonal regulation | E2 ↑ | [13] | E2 ↓ | [9, 10] | P4 | [13] | E2 ↓ + P4 | [13] |
| WNT5A | Function | Uterine wall morphogenesis | [19] | Hormonal regulation | E2 ↓ | [9, 10] | P4 + RU486 ↑ | [25] |
| WNT7A | Function | Development and functioning of the gonads | [6] | Postnatal uterine gland morphogenesis and function | [89] | Hormonal regulation | E2 ↓ | [9, 10] | E2 + P4 ↓ | [24] |
| CTNNB1 | Function | Normal functioning of the uterus Endometrial homeostasis | [32] | Hormonal regulation | P4 ↑ | [35] | E2 | [35] |
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↓: decreased gene expression; ↑: increased gene expression; E2: estradiol; P4: progesterone, RU486: antagonist of progesterone receptor.
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