Associations of LIG4 and HSPB1 Genetic Polymorphisms with Risk of Radiation-Induced Lung Injury in Lung Cancer Patients Treated with Radiotherapy

Table 1

Patient demographics and baseline disease characteristics.

	Patients ( = 160)	Ratio (%)
Age (years)	59.0 (25–75)
Gender
Male	126	78.8
Female	34	21.2
Smoking status
Smoker	120	75.0
Nonsmoker	40	25.0
Histological findings
Squamous cell carcinoma	50	31.2
Adenocarcinoma	40	25.0
Others	15	9.4
Small cell carcinoma	55	34.4
Stages of lung cancer
I	5	3.1
II	10	6.2
II	110	68.8
IV	35	21.9
Chemotherapy
Yes	127	79.4
No	33	20.6
Types of chemotherapy
CCRT	30	18.8
SCRT	20	12.5
	110	68.7
GTV (cm^3)	127.54 (13.12–780.36)
20 (lung-PTV) (%)	36 (3–75)

CCRT: concurrent chemoradiotherapy; SCRT: sequential chemoradiotherapy; GTV: gross tumor volume; PTV = planning target volume; 20 = percentage volume of structure receiving dose of 20 Gy or more.