Associations of LIG4 and HSPB1 Genetic Polymorphisms with Risk of Radiation-Induced Lung Injury in Lung Cancer Patients Treated with Radiotherapy

Table 4

Correlations of different genotypes in LIG4 (rs1805388) and HSPB1 (rs2868371) genetic polymorphisms with the risk of radiation pneumonitis in patients with lung cancer after radiation therapy.

Genotype	RP (%)	Non-RP (%)	OR (95% CI)
LIG4 rs1805388
CC	26 (81.2)	87 (68.0)	1	—
CT	6 (18.8)	31 (24.2)	0.648 (0.244–1.722)	0.381
TT	0 (0)	10 (7.8)	NC	NC
CT+TT	6 (18.8)	41 (32.0)	0.490 (0.187–1.282)	0.140
HSPB1 rs2868371
GG	14 (43.8)	50 (39.1)	1	—
GC	14 (43.8)	59 (46.1)	0.848 (0.369–1.946)	0.696
CC	4 (12.4)	19 (14.8)	0.752 (0.220–2.574)	0.649
GC+CC	18 (56.2)	78 (60.9)	0.824 (0.376–1.805)	0.628

RP: radiation pneumonitis; LIG4: Ligase IV; HSPB1: heat shock protein beta 1; OR: odds ratios; 95% CI: confidence intervals; NC: negative control.