Review Article
Role of NEK2A in Human Cancer and Its Therapeutic Potentials
Table 1
NEK2A interaction proteins and their functions.
| NEK2A interaction protein | Detection method | Function | Reference number |
| APC/C | Co-IP | NEK2A degradation | [23] | PP1 | Yeast two-hybrid, Co-IP | NEK2A dephosphorylation | [26, 27] | C-Nap1 | Yeast two-hybrid | Centrosome separation | [28] | Rootletin | Yeast two-hybrid | Centrosome separation | [29] | NLP2 | Yeast two-hybrid | Microtubule organization | [33] | Numatrin | Co-IP, pull-down | Centrosome integrity and dynamics | [37] | HMGA2 | Co-IP, pull-down | Chromatin condensation | [38] | HEC1 | Co-IP | Spindle assembly checkpoint, chromosome separation | [42] | MAD1 | Yeast two-hybrid, Co-IP | Spindle assembly checkpoint, chromosome separation | [40] | TRF1 | Yeast two-hybrid, pull-down | Chromosome separation | [41] | MAD2 | Co-IP | Spindle assembly checkpoint, chromosome separation | [12] | SGO1 | Pull-down, Co-IP | Chromosome congression | [43] |
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