Extraction Optimization for Obtaining Artemisia capillaris Extract with High Anti-Inflammatory Activity in RAW 264.7 Macrophage Cells

Table 2

Regression coefficients of the predicted second-order polynomial models and the results of an analysis of variance for LPS-induced PGE₂ and NO production and cytotoxicity in RAW 264.7 cells.

Source	LPS-induced PGE2 production			LPS-induced NO production			Cytotoxicity
	Coefficients	-value	value	Coefficients	-value	value	Coefficients	-value	value
	173.194583	8.42	<0.0001	175.977805	9.90	<0.0001	72.885069	9.10	<0.0001
Linear
	−2.523157	−5.11	0.0005	−2.059834	−4.82	0.0007	0.320093	1.66	0.1274
	−0.289006	−1.19	0.2625	−0.528652	−2.51	0.0308	−0.037478	−0.40	0.7010
	−11.023825	−4.38	0.0014	−12.992655	−5.97	0.0001	3.116604	3.18	0.0099
Quadratic
	0.019932	5.50	0.0003	0.016046	5.12	0.0005	−0.004113	−2.91	0.0155
	0.008825	6.76	<0.0001	0.010313	9.14	<0.0001	−0.002561	−5.04	0.0005
	0.660889	5.06	0.0005	0.686408	6.08	0.0001	−0.306064	−6.02	0.0001
Interaction
	−0.007467	−2.59	0.0268	−0.007997	−3.21	0.0093	0.002755	2.45	0.0340
	0.072940	2.53	0.0298	0.074690	3.00	0.0133	0.002083	0.19	0.8564
	−0.029131	−1.69	0.1228	−0.009278	−0.62	0.548	0.017361	2.58	0.0275
	1.366898			1.129981			1.635000
Total model		11.56	0.0003		17.10	<0.0001		16.97	0.0037
	0.9123			0.9390			0.8941
Adjusted	0.8334			0.8841			0.7988

Pure error of the sum of squares.