Research Article
Association of Environmental Arsenic Exposure, Genetic Polymorphisms of Susceptible Genes, and Skin Cancers in Taiwan
Table 3
Univariate analysis of genetic polymorphisms in glutathione S-transferase family, reactive oxidative stress genes, and DNA repair genes.
| | Gene | Case | Control |
OR (95% CI) | P value | | Number | (%) | Number | (%) | | | | |
| | GSTM1 | | | | | | | | | | | Nonnull | 25 | (35.71) | 86 | (41.15) | 1.00 | (Referent) | | | 0.42 | | Null | 45 | (64.29) | 123 | (58.85) | 1.26 | (0.72–2.21) | | |
| | GSTT1 | | | | | | | | | | | Nonnull | 27 | (38.57) | 109 | (52.15) | 1.00 | (Referent) | | | 0.05 | | Null | 43 | (61.43) | 100 | (47.85) | 1.74 | (1.00–3.02) | | |
| | GSTP1 (Ile105Val, rs1695) | | | | | | | | | | | W/W | 44 | (62.86) | 143 | (68.10) | 1.00 | (Referent) | 1.00 | (Referent) | 0.42 | | W/M | 26 | (37.14) | 59 | (28.10) | 1.47 | (0.83–2.61) | 1.26 | (0.72–2.22) | | M/M | 0 | — | 8 | (3.81) | — | — |
| | NQO1 (C609T, rs1800566) | | | | | | | | | | | C/C | 18 | (26.47) | 70 | (35.00) | 1.00 | (Referent) | 1.00 | (Referent) | 0.19 | | C/T | 36 | (52.94) | 104 | (52.00) | 1.35 | (0.71–2.56) | 1.50 | (0.81–2.76) | | T/T | 14 | (20.59) | 26 | (13.00) | 2.09 | (0.91–4.81) |
| | EPHX1 (Tyr113His, rs1051740) | | | | | | | | | | | T/T | 4 | (6.15) | 31 | (16.40) | 1.00 | (Referent) | 1.00 | (Referent) | 0.04 | | T/C | 27 | (41.54) | 56 | (29.63) | 3.74 | (1.20–11.66) | 2.99 | (1.01–8.83) | | C/C | 34 | (52.31) | 102 | (53.97) | 2.58 | (0.85–7.85) |
| | EPHX1 (His139Arg, rs2234922) | | | | | | | | | | | G/G | 0 | — | 4 | (1.94) | 1.00 | (Referent) | | | 0.49 | | A/G | 15 | (22.06) | 50 | (24.27) | | | | A/A | 53 | (77.94) | 152 | (73.79) | 0.80 | (0.42–1.53) | | |
| | HO-1 (5′-site GT repeats) | | | | | | | | | | | L/L | 17 | (26.15) | 47 | (23.62) | 1.00 | (Referent) | | | 0.87 | | S/L | 34 | (52.31) | 111 | (55.78) | | | | S/S | 14 | (21.54) | 41 | (20.60) | 1.06 | (0.53–2.10) | | |
| | XRCC1 (Arg280His, rs25489) | | | | | | | | | | | His/His | 0 | — | 4 | (1.93) | 1.00 | (Referent) | | | 0.16 | | Arg/His | 9 | (13.04) | 39 | (18.84) | | | | Arg/Arg | 60 | (86.96) | 164 | (79.23) | 1.75 | (0.80–3.80) | | |
| | XRCC1 (Arg399Gln, rs25487) | | | | | | | | | | | Arg/Arg | 35 | (50.72) | 114 | (55.34) | 1.00 | (Referent) | 1.00 | (Referent) | 0.50 | | Arg/Gln | 26 | (37.68) | 71 | (34.47) | 1.19 | (0.66–2.15) | 1.20 | (0.70–2.08) | | Gln/Gln | 8 | (11.59) | 21 | (10.19) | 1.24 | (0.51–3.05) |
| | XPD (C156A, rs238406) | | | | | | | | | | | CC | 10 | (14.93) | 54 | (26.34) | 1.00 | (Referent) | 1.00 | (Referent) | 0.05 | | AC | 40 | (59.70) | 110 | (53.66) | 1.96 | (0.91–4.22) | 2.04 | (0.99–4.27) | | AA | 17 | (25.37) | 41 | (20.00) | 2.24 | (0.93–5.40) |
| | hOGG1 (Ser326Cys, rs1052133) | | | | | | | | | | | Cys/Cys | 22 | (32.35) | 82 | (39.42) | 1.00 | (Referent) | 1.00 | (Referent) | 0.30 | | Ser/Cys | 37 | (54.41) | 103 | (49.52) | 1.34 | (0.73–2.45) | 1.36 | (0.76–2.43) | | Ser/Ser | 9 | (13.24) | 23 | (11.06) | 1.46 | (0.59–3.60) |
| | ATM (INV48 +238C>G, rs609429) | | | | | | | | | | | CC | 21 | (36.21) | 77 | (37.75) | 1.00 | (Referent) | 1.00 | (Referent) | 0.84 | | CG | 26 | (44.83) | 89 | (43.63) | 1.07 | (0.56–2.05) | 1.07 | (0.58–1.95) | | GG | 11 | (18.97) | 38 | (18.63) | 1.06 | (0.46–2.42) |
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