Research Article
Association of Environmental Arsenic Exposure, Genetic Polymorphisms of Susceptible Genes, and Skin Cancers in Taiwan
Table 4
Multivariate analysis of genetic polymorphisms in glutathione S-transferase family, reactive oxidative stress genes, and DNA repair genes.
| | Gene | Case | Control |
OR (95% CI) | value | | Number | (%) | Number | (%) | | | | |
| | GSTM1 | | | | | | | | | | | Nonnull | 25 | (35.71) | 86 | (41.15) | 1.00 | (Referent) | | | 0.46 | | Null | 45 | (64.29) | 123 | (58.85) | 1.26 | (0.68–2.39) | | |
| | GSTT1 | | | | | | | | | | | Nonnull | 27 | (38.57) | 109 | (52.15) | 1.00 | (Referent) | | | 0.30 | | Null | 43 | (61.43) | 100 | (47.85) | 1.36 | (0.76–2.46) | | |
| | GSTP1 (Ile105Val, rs1695) | | | | | | | | | | | W/W | 44 | (62.86) | 143 | (68.10) | 1.00 | (Referent) | 1.00 | (Referent) | 0.56 | | W/M | 26 | (37.14) | 59 | (28.10) | 1.17 | (0.57–2.37) | 1.21 | (0.64–2.30) | | M/M | 0 | — | 8 | (3.81) | — | — |
| | NQO1 (C609T, rs1800566) | | | | | | | | | | | C/C | 18 | (26.47) | 70 | (35.00) | 1.00 | (Referent) | 1.00 | (Referent) | 0.41 | | C/T | 36 | (52.94) | 104 | (52.00) | 1.08 | (0.51–2.29) | 1.33 | (0.68–2.58) | | T/T | 14 | (20.59) | 26 | (13.00) | 2.12 | (0.77–5.86) |
| | EPHX1 (Tyr113His, rs1051740) | | | | | | | | | | | T/T | 4 | (6.15) | 31 | (16.40) | 1.00 | (Referent) | 1.00 | (Referent) | 0.07 | | T/C | 27 | (41.54) | 56 | (29.63) | 3.25 | (1.01–10.54) | 2.71 | (0.90–8.25) | | C/C | 34 | (52.31) | 102 | (53.97) | 2.32 | (0.74–7.31) |
| | EPHX1 (His139Arg, rs2234922) | | | | | | | | | | | G/G | 0 | — | 4 | (1.94) | 1.00 | (Referent) | | | 0.35 | | A/G | 15 | (22.06) | 50 | (24.27) | | | | A/A | 53 | (77.94) | 152 | (73.79) | 0.71 | (0.35–1.48) | | |
| | HO-1 (5′-site GT repeats) | | | | | | | | | | | L/L | 17 | (26.15) | 47 | (23.62) | 1.00 | (Referent) | | | 0.45 | | S/L | 34 | (52.31) | 111 | (55.78) | | | | S/S | 14 | (21.54) | 41 | (20.60) | 0.94 | (0.42–2.08) | | |
| | XRCC1 (Arg280His, rs25489) | | | | | | | | | | | His/His | 0 | — | 4 | (1.93) | 1.00 | (Referent) | | | 0.39 | | Arg/His | 9 | (13.04) | 39 | (18.84) | | | | Arg/Arg | 60 | (86.96) | 164 | (79.23) | 0.69 | (0.28–1.62) | | |
| | XRCC1 (Arg399Gln, rs25487) | | | | | | | | | | | Arg/Arg | 35 | (50.72) | 114 | (55.34) | 1.00 | (Referent) | 1.00 | (Referent) | 0.76 | | Arg/Gln | 26 | (37.68) | 71 | (34.47) | 1.18 | (0.57–2.43) | 1.11 | (0.59–2.07) | | Gln/Gln | 8 | (11.59) | 21 | (10.19) | 0.90 | (0.30–2.66) |
| | XPD (C156A, rs238406) | | | | | | | | | | | CC | 10 | (14.93) | 54 | (26.34) | 1.00 | (Referent) | 1.00 | (Referent) | 0.17 | | AC | 40 | (59.70) | 110 | (53.66) | 1.60 | (0.72–3.55) | 1.71 | (0.79–3.69) | | AA | 17 | (25.37) | 41 | (20.00) | 2.06 | (0.82–5.19) |
| | hOGG1 (Ser326Cys, rs1052133) | | | | | | | | | | | Cys/Cys | 22 | (32.35) | 82 | (39.42) | 1.00 | (Referent) | 1.00 | (Referent) | 0.41 | | Ser/Cys | 37 | (54.41) | 103 | (49.52) | 1.16 | (0.57–2.37) | 0.77 | (0.41–1.45) | | Ser/Ser | 9 | (13.24) | 23 | (11.06) | 1.17 | (0.38–3.63) |
| | ATM (INV48 +238C>G, rs609429) | | | | | | | | | | | CC | 21 | (36.21) | 77 | (37.75) | 1.00 | (Referent) | 1.00 | (Referent) | 0.81 | | CG | 26 | (44.83) | 89 | (43.63) | 1.08 | (0.49–2.34) | 1.08 | (0.57–2.08) | | GG | 11 | (18.97) | 38 | (18.63) | 1.44 | (0.57–3.69) |
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OR adjusted for age, gender, cumulative arsenic exposure, and monomethylarsonic acid (MMA) percentage.
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