5 fractions/wk, 1.8–2.0 Gy/fraction on days 0–4 + cisplatin 40 mg/m2 on day 1
PAL 0.25 mg + PRED 100 mg o.d. on day 1, plus PRED 50 mg on day 2, and PRED 25 mg on days 3 and 4
During cycle 1, 42% nausea-free, after 5 cycles only 23% nausea-free
PAL & PRED insufficient for this treatment regimen
Dolasetron i.v.: no longer available in the USA (FDA 2010) and not recommended elsewhere (MASCC guidelines 2013). bCR: complete plus major response. cPrimary end point: CR days 1–5. dSecondary end point: CR days 1–15. p.o. = orally; i.v. = intravenously; b.i.d. = twice daily; wk = week; DEX = dexamethasone; DOL = dolasetron; GRAN = granisetron; MCP = metoclopramide; PAL = palonosetron; PRED = prednisolone; OND = ondansetron; PCP = prochlorperazine; TRO = tropisetron.