PPARα Agonist WY-14643 Induces SIRT1 Activity in Rat Fatty Liver Ischemia-Reperfusion Injury

Table 1

Effect of WY-14643 administration in hepatic injury in steatotic livers subjected to ischemia-reperfusion.

ALT
Sham	IR	WY-14643 + IR
97 ± 27,85	2675 ± 277,03	380 ± 86,02

Alanine aminotransferase (ALT) levels in plasma after 24 h of reperfusion. Sham: anesthesia and laparotomy, IR: 60 min partial ischemia and 24 h of reperfusion, and WY-14643 + IR: iv administration of WY-14643 (10 mg/kg) 1 hour before IR. versus Sham; versus IR.