Delay of Morphine Tolerance by Palmitoylethanolamide

Figure 1

Analgesia measurement, paw pressure test. Animals were treated daily with 30 mg kg⁻¹ PEA s.c. or with vehicle. The pain threshold was evaluated every day immediately before and 30 min after the injection i.p. of 10 mg kg⁻¹ morphine. Each value represents the mean ± SEM of 12 rats per group, performed in 2 different experimental sets. ^** versus pretest values.