Icariin Intervenes in Cardiac Inflammaging through Upregulation of SIRT6 Enzyme Activity and Inhibition of the NF-Kappa B Pathway

Figure 8

The effect of ICA on NF-κB (p65) nuclear translocation (relative quantification). (a) Young aortic ECs group (PBS and DMSO treatment). (b) Young + TNF-α group. (c) Young + TNF-α + ICA. (d) Young + TNF-α + ICA + PDTC. (e) Young + TNF-α + ICA + PDTC + Nicotinamide. Note: compared with normal group, ; compared with TNF-α group, ; compared with young + TNF-α + ICA group, ; and compared with young + TNF-α + ICA + PDTC group, .