Effects of Sevoflurane and Propofol on Organ Blood Flow in Left Ventricular Assist Devices in Pigs

Table 1

Markers of tissue injury and nitric oxide in both groups (propofol and sevoflurane) at baseline and 30 minutes after implantation of a left ventricular assist device.

	Propofol; = 5	Sevoflurane; = 5	values
ALT (U/L)
Baseline	29 ± 2	25 ± 2	0.221
PS 30′	29 ± 2	23 ± 2	0.048
AST (U/L)
Baseline	50 ± 10	35 ± 3	0.116
PS 30′	94 ± 46	44 ± 3	0.358
Bilirubin (mg/dL)
Baseline	0.25 ± 0.06	0.13 ± 0.02	0.081
PS 30′	0.24 ± 0.02	0.12 ± 0.04	0.028
GGT (U/L)
Baseline	63 ± 12	55 ± 8	0.584
PS 30′	62 ± 22	47 ± 8	0.496
AP (U/L)
Baseline	82 ± 8	72 ± 8	0.428
PS 30′	89 ± 12	79 ± 7	0.507
LDH (U/L)
Baseline	330 ± 19	331 ± 13	0.943
PS 30′	374 ± 18	347 ± 27	0.420
Creatinine (mg/dL)
Baseline	0.44 ± 0.03	0.57 ± 0.06	0.085
PS 30′	0.45 ± 0.03	0.47 ± 0.03	0.596
Urea (mg/dL)
Baseline	27.2 ± 2.2	22.2 ± 0.9	0.059
PS 30′	28.2 ± 2.6	22.2 ± 1.2	0.053
Lactic acid
Baseline	1.5 ± 0.5	1.1 ± 0.2	0.453
PS 30′	1.5 ± 0.3	1.2 ± 0.2	0.434
NO (μM)
Baseline	418 ± 47	691 ± 47	0.056
PS 30′	280 ± 92	478 ± 92	0.270

Data are expressed as the mean ± standard error of the mean. ALT: alanine transaminase; AST: aspartate aminotransferase; GGT: gamma-glutamyl transpeptidase; AP: alkaline phosphatase (AP); LDH: lactate dehydrogenase; NO: nitric oxide; PS: partial support. Statistically significant differences are shown. propofol versus sevoflurane.