Effects of Sevoflurane and Propofol on Organ Blood Flow in Left Ventricular Assist Devices in Pigs
Table 1
Markers of tissue injury and nitric oxide in both groups (propofol and sevoflurane) at baseline and 30 minutes after implantation of a left ventricular assist device.
Propofol = 5
Sevoflurane = 5
values
ALT (U/L)
Baseline
29 ± 2
25 ± 2
0.221
PS 30′
29 ± 2
23 ± 2
0.048
AST (U/L)
Baseline
50 ± 10
35 ± 3
0.116
PS 30′
94 ± 46
44 ± 3
0.358
Bilirubin (mg/dL)
Baseline
0.25 ± 0.06
0.13 ± 0.02
0.081
PS 30′
0.24 ± 0.02
0.12 ± 0.04
0.028
GGT (U/L)
Baseline
63 ± 12
55 ± 8
0.584
PS 30′
62 ± 22
47 ± 8
0.496
AP (U/L)
Baseline
82 ± 8
72 ± 8
0.428
PS 30′
89 ± 12
79 ± 7
0.507
LDH (U/L)
Baseline
330 ± 19
331 ± 13
0.943
PS 30′
374 ± 18
347 ± 27
0.420
Creatinine (mg/dL)
Baseline
0.44 ± 0.03
0.57 ± 0.06
0.085
PS 30′
0.45 ± 0.03
0.47 ± 0.03
0.596
Urea (mg/dL)
Baseline
27.2 ± 2.2
22.2 ± 0.9
0.059
PS 30′
28.2 ± 2.6
22.2 ± 1.2
0.053
Lactic acid
Baseline
1.5 ± 0.5
1.1 ± 0.2
0.453
PS 30′
1.5 ± 0.3
1.2 ± 0.2
0.434
NO (μM)
Baseline
418 ± 47
691 ± 47
0.056
PS 30′
280 ± 92
478 ± 92
0.270
Data are expressed as the mean ± standard error of the mean. ALT: alanine transaminase; AST: aspartate aminotransferase; GGT: gamma-glutamyl transpeptidase; AP: alkaline phosphatase (AP); LDH: lactate dehydrogenase; NO: nitric oxide; PS: partial support. Statistically significant differences are shown. propofol versus sevoflurane.