BioMed Research International

Research Article

The Effect of Bicarbonate Administration via Continuous Venovenous Hemofiltration on Acid-Base Parameters in Ventilated Patients

Table 3

Acid-base parameters and electrolytes^a.


	Hour 0	Hour 8	Hour 16	Hour 24	Hour 36	Hour 48	Hour 60	Hour 72	Hour 96

pH	7.32 ± 0.12	7.37 ± 0.08	7.37 ± 0.10	7.37 ± 0.08	7.39 ± 0.09	7.37 ± 0.08	7.38 ± 0.07	7.38 ± 0.07	7.37 ± 0.11
pH	(n = 18)	(n = 18)	(n = 18)	(n = 18)	(n = 19)	(n = 17)	(n = 18)	(n = 18)	(n = 17)

CO₂ (mmHg)	42.0 ± 14.6	37.3 ± 12.6	38.1 ± 9.7	39.9 ± 10.3	40.1 ± 11.6	39.4 ± 11.6	40.6 ± 10.3	42.2 ± 10.2	43.8 ± 16.1
CO₂ (mmHg)	(n = 18)	(n = 18)	(n = 18)	(n = 18)	(n = 19)	(n = 17)	(n = 18)	(n = 18)	(n = 17)

HCO₃ (mmol/L)^b	19.8 ± 5.1	20.1 ± 5.1	19.7 ± 4.2	22.3 ± 3.9	22.8 ± 3.7	23.1 ± 3.2	22.8 ± 3.5	23.3 ± 2.4	23.2 ± 3.8
HCO₃ (mmol/L)^b	(n = 19)	(n = 18)	(n = 18)	(n = 18)	(n = 19)	(n = 17)	(n = 18)	(n = 16)	(n = 16)

Base excess (mmol/L)	−5.2 ± 6.5	−4.2 ± 5.4	−3.9 ± 5.4	−3.3 ± 3.6	−2.2 ± 3.0	−2.3 ± 2.7	−1.8 ± 3.3	−1.2 ± 2.6	−1.4 ± 3.3
Base excess (mmol/L)	(n = 18)	(n = 18)	(n = 18)	(n = 18)	(n = 19)	(n = 17)	(n = 18)	(n = 18)	(n = 17)

Sodium (mmol/L)	132.7 ± 6.5	132.8 ± 5.1	132.5 ± 5.6	132.5 ± 5.9	132.1 ± 3.9	132.1 ± 3.9	132.1 ± 4.2	132.4 ± 4.1	131.1 ± 3.8
Sodium (mmol/L)	(n = 19)	(n = 18)	(n = 18)	(n = 18)	(n = 19)	(n = 17)	(n = 18)	(n = 16)	(n = 16)

Potassium (mmol/L)	4.9 ± 1.0	4.6 ± 0.8	4.6 ± 0.7	4.6 ± 0.7	4.5 ± 0.6	4.5 ± 0.8	4.4 ± 0.4	4.3 ± 0.5	4.5 ± 0.5
Potassium (mmol/L)	(n = 19)	(n = 19)	(n = 18)	(n = 19)	(n = 19)	(n = 19)	(n = 18)	(n = 17)	(n = 16)

Chloride (mmol/L)	96.4 ± 6.2	97.2 ± 5.7	97.4 ± 4.5	97.3 ± 5.4	98.5 ± 4.6	99.2 ± 3.5	98.2 ± 4.1	99.3 ± 3.7	98.8 ± 4.0
Chloride (mmol/L)	(n = 19)	(n = 18)	(n = 18)	(n = 18)	(n = 19)	(n = 17)	(n = 18)	(n = 16)	(n = 16)

Ionized calcium (mg/dL)	1.03 ± 0.1	1.08 ± 0.3	1.05 ± 0.1	1.04 ± 0.1	1.03 ± 0.1	1.08 ± 0.1	1.09 ± 0.1	1.11 ± 0.1	1.11 ± 0.1
Ionized calcium (mg/dL)	(n = 19)	(n = 16)	(n = 17)	(n = 19)	(n = 18)	(n = 16)	(n = 18)	(n = 16)	(n = 15)

BUN (mg/dL)	68.4 ± 35.8	60.2 ± 33.2	51.8 ± 27.1	45.4 ± 22.5	40.1 ± 20.2	37.5 ± 18.9	34.1 ± 16.4	30.5 ± 15.2	29.4 ± 14.6
BUN (mg/dL)	(n = 19)	(n = 18)	(n = 18)	(n = 18)	(n = 19)	(n = 17)	(n = 18)	(n = 16)	(n = 16)

Creatinine (mg/dL)	3.9 ± 1.2	3.5 ± 1.2	3.1 ± 1.1	2.8 ± 1.0	2.4 ± 1.0	2.3 ± 0.8	2.0 ± 0.7	2.0 ± 0.7	1.7 ± 0.7
Creatinine (mg/dL)	(n = 19)	(n = 18)	(n = 18)	(n = 18)	(n = 19)	(n = 17)	(n = 18)	(n = 16)	(n = 16)

Values presented as mean ± standard deviation.
^bDrawn from venous chemistry panel.
CO₂: partial arterial pressure of carbon dioxide, HCO₃: bicarbonate, and BUN: blood urea nitrogen.