Effects of the Chinese Herbal Formulation (Liu Wei Di Huang Wan) on the Pharmacokinetics of Isoflavones in Postmenopausal Women

Figure 1

Administration of soy milk and/or LWDHW in Phases A, B, and C (treatment in each phase was given in a fixed-sequence approach). Phase A, a single oral dose of 375 mL of soy milk; Phase B, a single oral dose of 375 mL of soy milk coadministered with a single oral dose of 6 g LWDHW; and Phase C, an oral administration of 6 g LWDHW three times daily for 14 days followed by a single oral dose of 375 mL of soy milk on the next day. Blood sample collection: before administration of soy milk and at 0.5, 1, 2, 4, 6, 8, 10, 12, 24, and 32 hours after administration of soy milk.