Effects of the Chinese Herbal Formulation (Liu Wei Di Huang Wan) on the Pharmacokinetics of Isoflavones in Postmenopausal Women

Table 1

Pharmacokinetic parameters of daidzein obtained following each of the three study phases in the 11 participants enrolled in the study.

Pharmacokinetic parameters	Treatment phase			value
	Phase A	Phase B	Phase C
(ng/mL)	772.64 ± 247.30	715.45 ± 207.16	804.00 ± 173.03	0.06
(h)	6.55 ± 2.02	6.64 ± 2.29	6.55 ± 1.81	0.97
(ng·h/mL)	7313.77 ± 3184.04	6234.05 ± 2536.89	7543.97 ± 2638.96	0.06
(ng·h/mL)	8169.06 ± 3056.75	7362.15 ± 2344.35	8416.20 ± 2522.09	0.18
(h)	4.42 ± 0.88	4.58 ± 1.06	4.14 ± 0.80	0.81

Friedman’s test.
Phase A, a single oral dose of soy milk; Phase B, a single oral dose of soy milk coadministered with LWDHW; Phase C, multiple oral doses of LWDHW for 14 days followed by a single oral dose of soy milk.