Effects of the Chinese Herbal Formulation (Liu Wei Di Huang Wan) on the Pharmacokinetics of Isoflavones in Postmenopausal Women

Table 2

Pharmacokinetic parameters of genistein obtained following each of the three study phases in the 11 participants enrolled in the study.

Pharmacokinetic parameters	Treatment phase			value
	Phase A	Phase B	Phase C
(ng/mL)	784.36 ± 371.67	670.36 ± 171.53	873.18 ± 336.34	0.09
(h)	5.36 ± 2.54	5.73 ± 2.28	6.00 ± 2.19	0.64
(ng·h/mL)	9062.53 ± 5237.58	7871.89 ± 3054.41	10534.08 ± 4730.12	0.53
(ng·h/mL)	9956.56 ± 5441.06	8544.75 ± 3053.48	11291.46 ± 5030.50	0.53
(h)	6.80 ± 0.62	6.69 ± 0.80	6.90 ± 0.89	0.91

Friedman’s test.
Phase A, a single oral dose of soy milk; Phase B, a single oral dose of soy milk coadministered with LWDHW; Phase C, multiple oral doses of LWDHW for 14 days followed by a single oral dose of soy milk.