Clinical Usefulness of Immunohistochemical Staining of p57^kip2 for the Differential Diagnosis of Complete Mole

Table 1

Fourteen equivocal cases subjected to polymer-based p57^kip2 immunohistochemistry for differentiation between complete and partial mole or hydropic abortion.

Case/patient	Age (yr)	G-P-A	Clinical Dx^*	hCG mIU/mL; before evacuation	Histopathologic; Dx	p57^kip2; staining	Final Dx
1	40	1-0-1	7 weeks	6700	Hydropic/partial	+	Hydropic/partial
2^**	30	3-3-0	7 weeks	4780	Partial/complete	−	Complete mole
3	40	2-2-0	7 weeks	49100	Partial/complete	+	Partial
4	27	3-2-1	8 weeks	83100	Partial/complete	+	Partial
5^**†	48	4-2-2	6 weeks	6590	partial/complete	−	Complete mole
6^**	30	3-1-2	7 weeks	28500	Partial/complete	−	Complete mole
7	27	1-1-0	8 weeks	91700	Hydropic/partial	+	Hydropic/partial
8	44	3-1-2	7 weeks	4670	Hydropic/partial	+	Hydropic/partial
9^**	27	1-1-0	6 weeks	31200	Partial/complete	−	Complete mole
10	34	2-1-1	7 weeks	7800	Partial/complete	+	Partial
11	34	2-1-1	8 weeks	4400	Partial/complete	+	Partial
12	33	0-0-0	5 weeks	4600	Partial/complete	+	Partial
13	32	1-1-0	6 weeks	6800	Hydropic/partial	+	Hydropic/partial
14	36	3-2-1	6 weeks	5200	Hydropic/partial	+	Hydropic/partial

G-P-A, gravida/para/abortus; hCG, human chorionic gonadotropin; dilation and curettage; Dx, diagnosis.
^*All diagnosed clinically as blighted ovum; ^**clearly differentiated as complete hydatidiform mole by polymer-based immunohistochemistry for p57^kip2; ^†hCG elevated to 8740, persistent trophoblastic disease, treated by single-agent chemotherapy.
S. SASAKI 2012.