Activation of Apoptotic Signal in Endothelial Cells through Intracellular Signaling Molecules Blockade in Tumor-Induced Angiogenesis

Figure 4

Simplified signaling network for lumen formation. The network in Figure 1 is simplified for use in the main signaling network. Cdc42 and Rac1 are integrated into a single node (Rac). The Rac activation mechanism by integrin is not expanded in this figure. Par3, Par6, and PKC are integrated into Par. Pak2 and Pak4 are integrated into Pak. Since the activation of Pak and Par nodes is parallel, they are also integrated in the main signaling network.