Activation of Apoptotic Signal in Endothelial Cells through Intracellular Signaling Molecules Blockade in Tumor-Induced Angiogenesis

Figure 5

Signaling cascade of EC phenotype determination and lumen formation. The double line in this figure represents cell boundary schematically. The environmental signals are transmitted into the cell through cell surface receptors. Each box represents an intracellular signaling molecule (or integration of a few molecules). The first line in each box is its title, and the second line is its Boolean dependence relation or activation rule. An arrow indicates an activation signal while a hammerhead indicates an inhibition. The intersections of horizontal and vertical lines do not represent any type of connection. The four lower boxes indicate cell phenotype and lumen formation. The activation of each phenotype and lumen formation depends on the combination of the inputs (cell surface receptor status).