Activation of Apoptotic Signal in Endothelial Cells through Intracellular Signaling Molecules Blockade in Tumor-Induced Angiogenesis

Figure 6

Signaling cascade of shear stress activation of EC. The double line in the figure represents cell boundary schematically. The shear stress induced signals are transmitted into the cell through cell surface receptors. Each box represents an intracellular signaling molecule. The first line in each box is the box title. The second line is the Boolean dependence relation or activation rule of the box. An arrow indicates an activation signal while a hammerhead indicates an inhibition signal. The intersections of horizontal and vertical lines do not represent any type of connection. The three lower boxes indicate cell phenotype.