Screening Active Compounds from Garcinia Species Native to China Reveals Novel Compounds Targeting the STAT/JAK Signaling Pathway

Table 1

The IC50s for the chosen 5 compounds and reference compound (staurosporine) against the 13 cancer cell lines and the control HuVec cell line.

Cell	GB32	GB39	GB40	GB49	GB63	Staurosporine
NCI-H838	3.15 ± 0.04	1.5 ± 0.07	1.68 ± 0.19	2.72 ± 0.15	2.65 ± 0.2	0.011 ± 0.004
A549	2.88 ± 0.06	3.04 ± 0.1	2.45 ± 0.06	3.46 ± 0.2	3.77 ± 0.06	0.008 ± 0.002
NCI-H1573	4.36 ± 0.15	6.08 ± 0.21	5.99 ± 0.19	7.89 ± 0.14	7.92 ± 0.29	0.039 ± 0.01
NCI-H1975	1.58 ± 0.12	1.25 ± 0.14	0.96 ± 0.05	1.69 ± 0.15	1.71 ± 0.22	0.002 ± 0.001
NCI-H1993	2.47 ± 0.11	1.03 ± 0.13	1.29 ± 0.05	2.55 ± 0.14	2.15 ± 0.1	0.021 ± 0.007
NCI-H1650	1.09 ± 0.15	0.95 ± 0.03	0.62 ± 0.03	0.97 ± 0.04	1.43 ± 0.09	0.022 ± 0.004
CHP212	1.45 ± 0.08	1.2 ± 0.08	1.18 ± 0.05	1.43 ± 0.03	3.51 ± 0.08	0.004 ± 0.001
U118MG	1.19 ± 0.07	1.15 ± 0.09	1.03 ± 0.15	1.22 ± 0.05	3.05 ± 0.1	0.003 ± 0.001
SW48	3.84 ± 0.09	1.44 ± 0.06	1.47 ± 0.1	2.97 ± 0.06	4.02 ± 0.15	0.025 ± 0.003
LnCap	1.8 ± 0.14	0.84 ± 0.08	0.79 ± 0.12	1.91 ± 0.06	2.17 ± 0.21	0.061 ± 0.009
SW954	2.43 ± 0.17	0.94 ± 0.04	1.02 ± 0.1	1.88 ± 0.1	2.58 ± 0.16	0.006 ± 0.001
SK-MEL-28	1.51 ± 0.07	0.82 ± 0.11	0.73 ± 0.21	1.51 ± 0.12	1.75 ± 0.16	0.37 ± 0.058
SW1353	1.41 ± 0.05	0.76 ± 0.03	0.83 ± 0.05	1.29 ± 0.05	2.48 ± 0.11	0.004 ± 0.001
HuVec	1.63 ± 0.06	0.89 ± 0.09	0.68 ± 0.01	1.47 ± 0.07	1.9 ± 0.03	0.004 ± 0.002