Effects of Acute Lithium Treatment on Brain Levels of Inflammatory Mediators in Poststroke Rats

Figure 2

Effects of lithium on brain inflammatory mediators levels of poststroke rats. At 2 h before surgery vehicle-treated rats were injected (ip) with 0.35 mL NaCl 0.9% and LiCl-treated rats with 100 mg/kg LiCl. At 24 h after surgery surviving rats were sacrificed and their brains were quickly excised. Then, FC, HC, and HT were excised and stored in −80°C. Levels of IL-1α (a), IL-6 (b), IL-10 (c), IL-12 (d), TNF-α (e), and PGE₂ (f) in brain regions were measured as described in Section 2. This figure represents the results of the second experiment of the study. The results in the first experiment were similar to those presented in this figure. Each column is the mean ± SEM of 6 (sham + Veh and sham + LiCl) or 12 (MCAO + Veh and MCAO + LiCl) rats per group. versus sham + Veh; versus MCAO + Veh. FC, frontal cortex; HC, hippocampus; HT, hypothalamus; LiCl, lithium chloride; MCAO, middle cerebral artery occlusion; UD, undetectable; Veh, vehicle.

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