Effects of Acute Lithium Treatment on Brain Levels of Inflammatory Mediators in Poststroke Rats

Table 1

Effects of lithium on mortality of poststroke rats.

Group	Sham + Veh	Sham + LiCl	value	MCAO + Veh	MCAO + LiCl	value
	9	9	NS	29	28	NS
Weight (g); mean ± SEM	363.4 ± 5.6	362.3 ± 4.7	NS	376.2 ± 3.9	378.3 ± 3.5	0.693
Rats with visible NDs at 24 h; number (%)	0 (0)	0 (0)	NS	21 (100)	21 (100)	NS
Mortality after 24 h; number (%)	0 (0)	0 (0)	NS	8 (27.6)	7 (25)	0.532

At 2 h before surgery vehicle-treated rats were injected (ip) with 0.35 mL NaCl 0.9% and LiCl-treated rats with 100 mg/kg lithium. Existence of NDs was assessed in surviving rats at 24 h after surgery as described in Section 2. Mortality was followed during 24 h after surgery. This table represents the results of the two experiments conducted in this study. Comparisons for statistical significance were done only between groups that underwent the same surgical procedure, that is, Sham + Veh versus Sham + LiCl; MCAO + Veh versus MCAO + LiCl. LiCl, lithium chloride; MCAO, middle cerebral artery occlusion; ND, neurological deficit; NS, nonsignificant; Veh, vehicle.