Elevation of Tim-3 and PD-1 Expression on T Cells Appears Early in HIV Infection, and Differential Tim-3 and PD-1 Expression Patterns Can Be Induced by Common γ-Chain Cytokines

Figure 1

Comparison of levels of differential expression patterns of Tim-3 and PD-1 (Tim-3+PD-1+, Tim-3-PD-1+, and Tim-3+PD-1−) on T cells in HIV-1 infected patients and normal controls. (a) Representative data regarding the expression patterns of Tim-3 and PD-1 in a normal control and in a chronic HIV-infected patient. (b) The percentages of differential Tim-3/PD-1 expression patterns on the CD4+ and CD8+ T cells of normal controls (NC, ), early HIV-infected patients (EHI, ), and chronic HIV-infected patients (CHI, ). (c) The percentages of Tim-3/PD-1 expression patterns on the CD4+ and CD8+ T cells of chronic HIV-infected patients with different CD4+ T-cell counts (more than or less than 350 cells/μL) and viral loads (more than or less than 20,000 copies/mL).

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