Research Article
Liver Failure Impairs the Intrahepatic Elimination of Interleukin-6, Tumor Necrosis Factor-Alpha, Hepatocyte Growth Factor, and Transforming Growth Factor-Beta
Table 1
Demographic and clinical data of the study group. F: female, M: male, and SD: standard deviation.
| | Parameter | No liver cirrhosis (NLC) | Liver cirrhosis (LC) |
| | Sex F/M [ (%)] | 5 (25)/15 (75) | 11 (55)/9 (45) | | Age [years (SD)] | 35.3 (12.7) | 50.1 (8.5) | | Cause of death [ (%)] | | | | Craniocerebral trauma | 9 (45) | | | Hemorrhagic stroke | 9 (45) | | | Subarachnoid hemorrhage | 2 (10) | | | Child-Pugh class [ (%)] | | | | B | | 13 (65) | | C | | 7 (35) | | Cause of liver failure [ (%)] | | | | Unknown | | 6 (30) | | Primary biliary cirrhosis (PBC) | | 3 (15) | | Alcoholic liver disease (ALD) | | 3 (15) | | Hepatitis C cirrhosis (HCV) | | 3 (15) | | HBV + HCV cirrhosis | | 2 (10) | | Primary sclerosing cholangitis (PSC) | | 1 (5) | | Autoimmune hepatitis (AIH) | | 1 (5) | | AIH + HBV | | 1 (5) | | AlAT (U/L) [mean (SD/range)] | 29.2 (16.1) | 458 (11–6766) | | GGTP (U/L) [mean (SD/range)] | 24.1 (17.1) | 188.5 (38–476) | | INR [mean (SD/range)] | 1.2 (0.2) | 1.4 (0.86–4.0) | | Creatinine (mg/mL) [mean (SD/range)] | 0.9 (0.24) | 1.0 (0.3) | | Interleukin-6 (Il-6) [median (range) ng/ml] | | | | Portal vein | 0.31 (0.12–0.90) | 0.40 (0.21–0.62) | | Hepatic vein | 0.21 (0.02–0.44) | 0.39 (0.19–0.88) | | Hepatic artery | 0.21 (0.01–1.07) | 0.22 (0.01–0.60) | | Peripheral vein | 0.27 (0.02–0.74) | 0.38 (0.04–0.55) | | Tumor necrosis factor-alpha (TNF-α) [median (range) ng/ml] | | | | Portal vein (PV) | 10.52 (2.98–35.81) | 8.97 (1.98–19.68) | | Hepatic vein (HV) | 4.22 (0.48–22.36) | 7.46 (2.47–22.36) | | Hepatic artery (HA) | 6.32 (0.59–36.11) | 9.95 (1.48–45.27) | | Peripheral vein (PhV) | 3.40 (0.48–38.01) | 8.94 (0.24–21.59) | | Hepatocyte growth factor (HGF) [median (range) ng/ml] | | | | Portal vein (PV) | 1.60 (1.00–6.18) | 2.19 (0.97–4.02) | | Hepatic vein (HV) | 1.34 (0.71–2.92) | 2.87 (1.12–8.94) | | Hepatic artery (HA) | 1.47 (0.92–4.38) | 2.09 (0.72–4.50) | | Peripheral vein (PhV) | 1.55 (0.52–5.32) | 2.66 (0.99–5.96) | | Transforming growth factor-beta (TGF-β) [median (range) ng/ml] | | | | Portal vein (PV) | 10.38 (3.69–28.29) | 5.52 (2.96–24.60) | | Hepatic vein (HV) | 7.05 (3.42–15.82) | 6.38 (4.85–18.78) | | Hepatic artery (HA) | 8.82 (2.68–23.24) | 3.87 (1.52–11.83) | | Peripheral vein (PhV) | 10.38 (1.21–26.08) | 7.08 (1.91–21.19) |
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