Zoledronic Acid May Reduce Intraoperative Bleeding in Spinal Tumors: A Prospective Cohort Study

Table 3

Comparison of intraoperative blood loss and surgical approach in 157 patients with metastases.

Intraoperative blood loss	Preoperative zoledronic acid group (group A; )	Control group (group B; )
Mean ± SD (volume per milliliter)	1311 ± 691	1752 ± 740	0.000
Range (volume per milliliter)	380–3400	450–4200
Distribution			0.001
≤500 mL	10	3
500–1000 mL	26	8
1001–1500 mL	17	20
1501–2000 mL	18	25
≥2001 mL	10	20
Surgical approach			0.704
Anterior	12	14
Posterior	67	59
Combined	2	3