Histamine Induces Alzheimer’s Disease-Like Blood Brain Barrier Breach and Local Cellular Responses in Mouse Brain Organotypic Cultures

Figure 4

Histamine is able to induce pathological changes in MBO cultures, regardless of their thickness. Treatment of both 1 mm (a) and 2 mm (b) thick MBO cultures with histamine leads to an increase in blood vessel leakage, astrocyte activation, and neuronal damage responses, compared to controls. Mean ± SEM is used to represent the variations within each group. ; ; .

(a)

(b)